Recombinant Human Programmed cell death 6-interacting protein (PDCD6IP), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 32.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Programmed cell death 6-interacting protein (PDCD6IP), partial

Recombinant Human Programmed cell death 6-interacting protein (PDCD6IP), partial — (Microbial infection) Involved in HIV-1 virus budding. Purity >90%.

SKU: BCRECP-001362 Category:
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Product Specifications

Product SkuBCRECP-001362
Product DescriptionRecombinant Human Programmed cell death 6-interacting protein (PDCD6IP) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 402-652aa. [Accession | Q8WUM4].
Uniprot No.Q8WUM4
Gene NamesPDCD6IP
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region402-652aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight32.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

(Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).

Biological Context

Subcellular Location: Cytoplasm, cytosol; Melanosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Secreted, extracellular exosome; Cell junction, tight junction; Midbody, Midbody ring
Disease Association: Microcephaly 29, primary, autosomal recessive (MCPH29) : A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH29 is characterized by small head circumference apparent at birth and associated with global developmental delay, impaired intellectual development, speech delay, and behavioral abnormalities. Affected individuals also have poor overall growth with short stature, mild dysmorphic facial features, and seizures. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Programmed cell death 6-interacting protein (PDCD6IP), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 402-652aa, with N-terminal 6xHis-tagged tag, molecular weight 32.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

(Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses)

Subcellular Location

Cytoplasm, cytosol; Melanosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Secreted, extracellular exosome; Cell junction, tight junction; Midbody, Midbody ring

Disease Association

Microcephaly 29, primary, autosomal recessive (MCPH29) : A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH29 is characterized by small head circumference apparent at birth and associated with global developmental delay, impaired intellectual development, speech delay, and behavioral abnormalities. Affected individuals also have poor overall growth with short stature, mild dysmorphic facial features, and seizures. [The disease may be caused by variants affecting the gene represented in this entry]

Subunit

(Microbial infection) Interacts with ebola virus protein VP40 (via YPx(n)L/I motif)

Gene: PDCD6IP  |  Organism: Homo sapiens  |  Synonyms: ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95
Key Publications

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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