Recombinant Human Programmed cell death 6-interacting protein (PDCD6IP), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 32.3kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Programmed cell death 6-interacting protein (PDCD6IP), partial

Recombinant Human Programmed cell death 6-interacting protein (PDCD6IP), partial — (Microbial infection) Involved in HIV-1 virus budding. Purity >90%.

SKU: BCRECP-001362 Categories: ,
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Product Specifications

Product SkuBCRECP-001362
Product DescriptionRecombinant Human Programmed cell death 6-interacting protein (PDCD6IP) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 402-652aa. [Accession | Q8WUM4].
Uniprot No.Q8WUM4
Gene NamesPDCD6IP
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region402-652aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight32.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

(Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).

Biological Context

Subcellular Location: Cytoplasm, cytosol; Melanosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Secreted, extracellular exosome; Cell junction, tight junction; Midbody, Midbody ring
Disease Association: Microcephaly 29, primary, autosomal recessive (MCPH29) : A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH29 is characterized by small head circumference apparent at birth and associated with global developmental delay, impaired intellectual development, speech delay, and behavioral abnormalities. Affected individuals also have poor overall growth with short stature, mild dysmorphic facial features, and seizures. [The disease may be caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Programmed cell death 6-interacting protein (PDCD6IP), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 402-652aa, with N-terminal 6xHis-tagged tag, molecular weight 32.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

(Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses)

Subcellular Location

Cytoplasm, cytosol; Melanosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Secreted, extracellular exosome; Cell junction, tight junction; Midbody, Midbody ring

Disease Association

Microcephaly 29, primary, autosomal recessive (MCPH29) : A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH29 is characterized by small head circumference apparent at birth and associated with global developmental delay, impaired intellectual development, speech delay, and behavioral abnormalities. Affected individuals also have poor overall growth with short stature, mild dysmorphic facial features, and seizures. [The disease may be caused by variants affecting the gene represented in this entry]

Subunit

(Microbial infection) Interacts with ebola virus protein VP40 (via YPx(n)L/I motif)

Gene: PDCD6IP  |  Organism: Homo sapiens  |  Synonyms: ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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