Recombinant Human Prolactin receptor (PRLR), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 27.2 kDa, purity >95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.

Recombinant Human Prolactin receptor (PRLR), partial (Active)

Recombinant Human Prolactin receptor (PRLR), partial (Active) — This is a receptor for the anterior pituitary hormone prolactin (PRL). Purity >95%.

SKU: BCACP-000164 Category:
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Product SKUBCACP-000164
Product DescriptionRecombinant Human Prolactin receptor (PRLR) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 25-234aa. [Accession | P16471].
Uniprot No.P16471
Gene NamesPRLR
PurityGreater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region25-234aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight27.2 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human CCR6 at 10 μg/mL can bind Anti-CCR6 recombinant antibody . The EC50 is 44.79-56.10 ng/mL.The VLPs is negative control.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesPRLR; Prolactin receptor; PRL-R

Function

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in breast, placenta, kidney, liver and pancreas
Disease Association: Multiple fibroadenomas of the breast (MFAB) : A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue. [The disease is caused by variants affecting the gene represented in this entry] | Hyperprolactinemia (HPRL) : A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Prolactin receptor (PRLR), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 25-234aa, with C-terminal 10xHis-tagged tag, molecular weight 27.2 kDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR6 at 10 μg/mL can bind Anti-CCR6 recombinant antibody . The EC50 is 44.79-56.10 ng/mL.The VLPs is negative control.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling

Subcellular Location

Secreted

Disease Association

Multiple fibroadenomas of the breast (MFAB) : A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue. [The disease is caused by variants affecting the gene represented in this entry] | Hyperprolactinemia (HPRL) : A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in breast, placenta, kidney, liver and pancreas

Subunit

Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent

Gene: PRLR  |  Organism: Homo sapiens
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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