Recombinant Human Protein deacetylase HDAC6 (HDAC6), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 42.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Protein deacetylase HDAC6 (HDAC6), partial

Recombinant Human Protein deacetylase HDAC6 (HDAC6), partial — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-000809 Category:
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Product Specifications

Product SkuBCRECP-000809
Product DescriptionRecombinant Human Protein deacetylase HDAC6 (HDAC6) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 489-840aa. [Accession | Q9UBN7].
Uniprot No.Q9UBN7
Gene NamesHDAC6
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region489-840aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight42.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

(Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication.

Biological Context

Subcellular Location: Cytoplasm; Cytoplasm, cytoskeleton; Nucleus; Perikaryon; Cell projection, dendrite; Cell projection, axon; Cell projection, cilium; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, cilium basal body
Disease Association: Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM) : A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild intellectual disability. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Protein modification; protein ubiquitination

Product Specifications

Recombinant Human Protein deacetylase HDAC6 (HDAC6), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 489-840aa, with N-terminal 6xHis-tagged tag, molecular weight 42.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

(Microbial infection) Deacetylates the SARS-CoV-2 N protein which promotes association of the viral N protein with human G3BP1, leading to disruption of cellular stress granule formation and facilitating viral replication

Subcellular Location

Cytoplasm; Cytoplasm, cytoskeleton; Nucleus; Perikaryon; Cell projection, dendrite; Cell projection, axon; Cell projection, cilium; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, cilium basal body

Disease Association

Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM) : A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild intellectual disability. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

(Microbial infection) Interacts with G3BP1; the interaction increases during SARS-CoV-2 infection, promoting the association of G3BP1 with the viral N protein which disrupts stress granule formation and facilitates viral replication

Pathway

Protein modification; protein ubiquitination

Gene: HDAC6  |  Organism: Homo sapiens  |  Synonyms: E3 ubiquitin-protein ligase HDAC6; Tubulin-lysine deacetylase HDAC6
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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