Recombinant Human Protein-lysine 6-oxidase (LOX), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 32.4kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Protein-lysine 6-oxidase (LOX), partial

Recombinant Human Protein-lysine 6-oxidase (LOX), partial — Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Purity >90%.

SKU: BCRECP-001078 Categories: ,
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Product Specifications

Product SkuBCRECP-001078
Product DescriptionRecombinant Human Protein-lysine 6-oxidase (LOX) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 174-417aa. [Accession | P28300].
Uniprot No.P28300
Gene NamesLOX
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region174-417aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight32.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression.

Biological Context

Subcellular Location: Secreted; Secreted, extracellular space
Tissue Specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas
Disease Association: Aortic aneurysm, familial thoracic 10 (AAT10) : A form of thoracic aortic aneurysm, a disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Protein-lysine 6-oxidase (LOX), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 174-417aa, with N-terminal 6xHis-tagged tag, molecular weight 32.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity)

Subcellular Location

Secreted; Secreted, extracellular space

Disease Association

Aortic aneurysm, familial thoracic 10 (AAT10) : A form of thoracic aortic aneurysm, a disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Heart, placenta, skeletal muscle, kidney, lung and pancreas

Subunit

Interacts with MFAP4 (PubMed:26601954). Interacts (via propeptide) with EFEMP2; this interaction is strong and facilitates formation of ternary complexes with ELN during elastic fiber assembly; this interaction limits interaction of EFEMP2 with FBLN5 (PubMed:19855011)

Gene: LOX  |  Organism: Homo sapiens  |  Synonyms: Lysyl oxidase
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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