Recombinant Human Retinol-binding protein 4 (RBP4) (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 50.0 kDa, purity >90% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.

Recombinant Human Retinol-binding protein 4 (RBP4) (Active)

Recombinant Human Retinol-binding protein 4 (RBP4) (Active) — Retinol-binding protein that mediates retinol transport in blood plasma. Purity >90%.

SKU: BCACP-000085 Category:
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Product SKUBCACP-000085
Product DescriptionRecombinant Human Retinol-binding protein 4 (RBP4) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 19-201aa. [Accession | P02753].
Uniprot No.P02753
Gene NamesRBP4
PurityGreater than 90% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.
Expression SystemMammalian cell
Expression Region19-201aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight50.0 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized TNFRSF14 at 5 μg/ml can bind TNFSF14, the EC50 is 45.44-53.29 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(Plasma retinol-binding protein)(PRBP)(RBP)

Function

Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Detected in blood plasma and in urine (at protein level)
Disease Association: Retinal dystrophy, iris coloboma, and comedogenic acne syndrome (RDCCAS) : A disease characterized by retinal degeneration, ocular colobomas involving both the anterior and posterior segment, impaired night vision and loss of visual acuity. Additional characteristic features include developmental abnormalities and severe acne. [The disease is caused by variants affecting the gene represented in this entry. Loss of functional RBP4 protein results in serum retinol deficiency. Lack of normal levels of retinol impairs the visual cycle leading to night blindness at early stages; prolonged deficiency may lead to retinal degeneration. Additionally, retinol deficiency may result in dry skin, increased susceptibility to infection and acne ] | Microphthalmia/Coloboma 10 (MCOPCB10) : A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Retinol-binding protein 4 (RBP4) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 19-201aa, with C-terminal hFc1-tagged tag, molecular weight 50.0 kDa, purity Greater than 90% as determined by SDS-PAGE.Greater than 90% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized TNFRSF14 at 5 μg/ml can bind TNFSF14, the EC50 is 45.44-53.29 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496)

Subcellular Location

Secreted

Disease Association

Retinal dystrophy, iris coloboma, and comedogenic acne syndrome (RDCCAS) : A disease characterized by retinal degeneration, ocular colobomas involving both the anterior and posterior segment, impaired night vision and loss of visual acuity. Additional characteristic features include developmental abnormalities and severe acne. [The disease is caused by variants affecting the gene represented in this entry. Loss of functional RBP4 protein results in serum retinol deficiency. Lack of normal levels of retinol impairs the visual cycle leading to night blindness at early stages; prolonged deficiency may lead to retinal degeneration. Additionally, retinol deficiency may result in dry skin, increased susceptibility to infection and acne (PubMed:23189188)] | Microphthalmia/Coloboma 10 (MCOPCB10) : A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Detected in blood plasma and in urine (at protein level)

Subunit

Interacts with TTR (PubMed:10052934, PubMed:19021760, PubMed:5541771, PubMed:7754382). Interaction with TTR prevents its loss by filtration through the kidney glomeruli (Probable). Interacts with STRA6 (PubMed:22665496, PubMed:25910211)

Gene: RBP4  |  Organism: Homo sapiens  |  Synonyms: Plasma retinol-binding protein
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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