Recombinant Human Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1), partial Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 49.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1), partial Protein

Recombinant Human Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1), partial Protein — Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Purity >90%.

SKU: BCRECP-00371TM Category:
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Product Specifications

Uniprot No.O14983
Gene NamesATP2A1
PurityGreater than 90% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region10-450aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight49.5kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Multi-pass membrane protein); Sarcoplasmic reticulum membrane (Multi-pass membrane protein)
Tissue Specificity: Skeletal muscle, fast twitch muscle (type II) fibers
Disease Association: Brody disease (BROD) : An autosomal recessive muscular disorder characterized by exercise-induced muscle stiffness and cramps primarily affecting the arms, legs, and eyelids, although more generalized muscle involvement may also occur. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1), partial Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 10-450aa, with N-terminal 10xHis-tagged tag, molecular weight 49.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not Test

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677)

Subcellular Location

Endoplasmic reticulum membrane (Multi-pass membrane protein); Sarcoplasmic reticulum membrane (Multi-pass membrane protein)

Disease Association

Brody disease (BROD) : An autosomal recessive muscular disorder characterized by exercise-induced muscle stiffness and cramps primarily affecting the arms, legs, and eyelids, although more generalized muscle involvement may also occur. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Skeletal muscle, fast twitch muscle (type II) fibers

Subunit

Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN). Interacts with DWORF (By similarity). Interacts with VMP1 (PubMed:28890335)

Gene: ATP2A1  |  Organism: Homo sapiens  |  Synonyms: Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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