Recombinant Human Semaphorin-7A (SEMA7A), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 70.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Semaphorin-7A (SEMA7A)

Recombinant Human Semaphorin-7A (SEMA7A) — Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Purity >90%.

SKU: BCRECP-001605 Category:
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Product Specifications

Product SkuBCRECP-001605
Product DescriptionRecombinant Human Semaphorin-7A (SEMA7A) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 45-648aa. [Accession | O75326].
Uniprot No.O75326
Gene NamesSEMA7A
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region45-648aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight70.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages.

Biological Context

Subcellular Location: Cell membrane (Lipid-anchor, GPI-anchor)
Tissue Specificity: Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal cord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney
Disease Association: Cholestasis, progressive familial intrahepatic, 11 (PFIC11) : An autosomal recessive form of progressive cholestasis, a disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Semaphorin-7A (SEMA7A) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 45-648aa, with N-terminal 6xHis-tagged tag, molecular weight 70.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor)

Disease Association

Cholestasis, progressive familial intrahepatic, 11 (PFIC11) : An autosomal recessive form of progressive cholestasis, a disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal cord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney

Subunit

Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1

Gene: SEMA7A  |  Organism: Homo sapiens  |  Synonyms: CDw108; JMH blood group antigen; John-Milton-Hargen human blood group Ag; Semaphorin-K1; Semaphorin-L
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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