Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active), Homo sapiens (Human), Baculovirus, C-terminal 6xHis-tagged, 11.5KDa, purity >95% as determined by SDS-PAGE.
, ,

Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active)

Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active) — Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. Purity >95%.

SKU: BCRECP-000030 Categories: , ,
Online Inquiry →

Product Specifications

Product SkuBCRECP-000030
Product DescriptionRecombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1) Protein is expressed from Baculovirus with C-terminal 6xHis-tagged. It contains 22-118aa. [Accession | P37023].
Uniprot No.P37023
Gene NamesACVRL1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemBaculovirus
Expression Region22-118aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight11.5KDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Disease Association: Telangiectasia, hereditary hemorrhagic, 2 (HHT2) : A multisystemic vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera. The disease is characterized by recurrent epistaxis and gastro-intestinal hemorrhage. Visceral involvement includes arteriovenous malformations of the lung, liver, and brain. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Serine/threonine-protein kinase receptor R3 (ACVRL1), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Baculovirus, covering amino acids 22-118aa, with C-terminal 6xHis-tagged tag, molecular weight 11.5KDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Disease Association

Telangiectasia, hereditary hemorrhagic, 2 (HHT2) : A multisystemic vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera. The disease is characterized by recurrent epistaxis and gastro-intestinal hemorrhage. Visceral involvement includes arteriovenous malformations of the lung, liver, and brain. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Interacts with TSC22D1/TSC-22

Gene: ACVRL1  |  Organism: Homo sapiens  |  Synonyms: Activin receptor-like kinase 1; Serine/threonine-protein kinase receptor R3; TGF-B superfamily receptor type I
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

Shopping Cart
Scroll to Top