Recombinant Macaca fascicularis Serine/threonine-protein kinase receptor (ACVRL1), partial (Active), Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey), Baculovirus, C-terminal 6xHis-tagged, 11.59kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Macaca fascicularis Serine/threonine-protein kinase receptor (ACVRL1), partial (Active)

Recombinant Macaca fascicularis Serine/threonine-protein kinase receptor (ACVRL1), partial (Active) — Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. Purity >95%.

SKU: BCACP-000470 Categories: , ,
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Product SKUBCACP-000470
Product DescriptionRecombinant Cynomolgus monkey Serine/threonine-protein kinase receptor (ACVRL1) protein is expressed from Baculovirus with C-terminal 6xHis-tagged. It contains 22-118aa. [Accession | A0A2K5WXU2].
Uniprot No.A0A2K5WXU2
Gene NamesACVRL1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemBaculovirus
Expression Region22-118aa
SpeciesMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Tag InfoC-terminal 6xHis-tagged
Molecular weight11.59kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis L1CAM at 2 μg/mL can bind Anti-L1CAM recombinant antibody. The EC50 is 1.496-1.709 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesSerine/threonine-protein kinase receptor; EC:2.7.11.30; ACVRL1

Function

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Product Specifications

Recombinant Macaca fascicularis Serine/threonine-protein kinase receptor (ACVRL1), partial (Active) is a recombinant protein, expressed in Baculovirus, covering amino acids 22-118aa, with C-terminal 6xHis-tagged tag, molecular weight 11.59kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well

Organism: Macaca fascicularis

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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