Function
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.
Biological Context
Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Detected in monocytes and dendritic cells
Product Specifications
Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 30-371aa, with C-terminal 10xHis-tagged tag, molecular weight 38.6 kDa, purity Greater than 95% as determined by SDS-PAGE.Greater than 95% as determined by SEC-HPLC.. Suitable for ELISA and Western Blot applications.
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human C5 at 2 μg/mL can bind Anti-C5 recombinant antibody . The EC50 is 1.867-2.192 ng/mL.;C5 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human C5 with an affinity constant of 0.285 nM as detected by MetaSPR Assay (WeSPRTM 200).
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
