Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial

Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial — Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Purity >90%.

SKU: BCRECP-001637 Category:

Product Specifications

Product SkuBCRECP-001637
Product DescriptionRecombinant Human Signal-regulatory protein beta-1 (SIRPB1) Protein is expressed from Mammalian cell with N-terminal 6xHis-Myc-tagged. It contains 30-371aa. [Accession | O00241].
Uniprot No.O00241
Gene NamesSIRPB1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region30-371aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-Myc-tagged
Molecular weight41.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Detected in monocytes and dendritic cells

Product Specifications

Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 30-371aa, with N-terminal 6xHis-Myc-tagged tag, molecular weight 41.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Protein Biology

Function

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985)

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Tissue Specificity

Detected in monocytes and dendritic cells

Subunit

Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK

Gene: SIRPB1  |  Organism: Homo sapiens  |  Synonyms: CD172 antigen-like family member B
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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