Recombinant Human Signal transducer CD24 (CD24)-Nanoparticle (Active)

Function

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity)

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor)

Disease Association

Multiple sclerosis (MS) : A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. [Disease susceptibility may be associated with variants affecting the gene represented in this entry]

Tissue Specificity

B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells

Subunit

Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562 and in Burkitt's lymphoma

• Kay R. et al. CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor. — J. Immunol. (1991)
• Jackson D. et al. CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. — Cancer Res. (1992)
• Wang L. et al. A dinucleotide deletion in CD24 confers protection against autoimmune diseases. — PLoS Genet. (2007)
• Kwon M.J. et al. CD24 overexpression is associated with poor prognosis in luminal a and triple-negative breast cancer. — PLoS ONE (2015)
• Kalnine N. et al. Cloning of human full-length CDSs in BD Creator(TM) system donor vector. (MAY-)
• Mungall A.J. et al. The DNA sequence and analysis of human chromosome 6. — Nature (2003)
• Kimura K. et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. — Genome Res. (2006)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)