Recombinant Human Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 60.2kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9) Protein

Recombinant Human Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9) Protein — High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules. Purity >85%.

SKU: BCRECP-00426TM Category:
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Product Specifications

Uniprot No.Q9NRM0
Gene NamesSLC2A9
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-540aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight60.2kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules. May have a residual high-affinity, low-capacity glucose and fructose transporter activity. Transports urate at rates 45- to 60-fold faster than glucose.

Biological Context

Subcellular Location: Cell membrane; Apical cell membrane (Multi-pass membrane protein); Basolateral cell membrane (Multi-pass membrane protein)
Tissue Specificity: Only detected in the apical membranes of polarized renal tubular cells and placenta. Detected in kidney membrane (at protein level)
Disease Association: Hypouricemia renal 2 (RHUC2) : A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-540aa, with N-terminal 10xHis-tagged tag, molecular weight 60.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules (PubMed:18327257, PubMed:18701466, PubMed:22647630, PubMed:28083649, PubMed:36749388). May have a residual high-affinity, low-capacity glucose and fructose transporter activity (PubMed:18327257, PubMed:18701466, PubMed:18842065). Transports urate at rates 45- to 60-fold faster than glucose (PubMed:18842065). Does not transport galactose (PubMed:28083649). May mediate small uptake of adenine but not of other nucleobases (PubMed:22647630)

Subcellular Location

Cell membrane; Apical cell membrane (Multi-pass membrane protein); Basolateral cell membrane (Multi-pass membrane protein)

Disease Association

Hypouricemia renal 2 (RHUC2) : A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Only detected in the apical membranes of polarized renal tubular cells and placenta. Detected in kidney membrane (at protein level)

Gene: SLC2A9  |  Organism: Homo sapiens  |  Synonyms: Glucose transporter type 9; Urate transporter
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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