Recombinant Human Somatotropin (GH1) (Active), Homo sapiens (Human), Mammalian cell, Tag free, 22.0 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Somatotropin (GH1) (Active)

Recombinant Human Somatotropin (GH1) (Active) — Plays an important role in growth control. Purity >95%.

SKU: BCACP-001131 Category:
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Product SKUBCACP-001131
Product DescriptionRecombinant Human Somatotropin (GH1) protein is expressed from Mammalian cell with Tag free. It contains 27-217aa. [Accession | P01241].
Uniprot No.P01241
Gene NamesGH
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region27-217aa
SpeciesHomo sapiens (Human)
Tag InfoTag free
Molecular weight22.0 kDa
ActivityMeasured in a VSV inhibition assay with Wish cells. The ED50 this effect is ≤100 pg/mL, corresponding to a specific activity is ≥1 ×10^7 units/mg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesGH1;Somatotropin;Growth hormone;GH;GH-N;Growth hormone 1;Pituitary growth hormone

Function

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts.

Biological Context

Subcellular Location: Secreted
Disease Association: Growth hormone deficiency, isolated, 1A (IGHD1A) : An autosomal recessive, severe deficiency of growth hormone leading to dwarfism. Patients often develop antibodies to administered growth hormone. [The disease is caused by variants affecting the gene represented in this entry] | Growth hormone deficiency, isolated, 1B (IGHD1B) : An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy. [The disease is caused by variants affecting the gene represented in this entry] | Kowarski syndrome (KWKS) : A syndrome clinically characterized by short stature associated with bioinactive growth hormone, normal or slightly increased growth hormone secretion, pathologically low insulin-like growth factor 1 levels, and normal catch-up growth on growth hormone replacement therapy. [The disease is caused by variants affecting the gene represented in this entry] | Growth hormone deficiency, isolated, 2 (IGHD2) : An autosomal dominant deficiency of growth hormone leading to short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Somatotropin (GH1) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 27-217aa, with Tag free tag, molecular weight 22.0 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues

Subcellular Location

Secreted

Disease Association

Growth hormone deficiency, isolated, 1A (IGHD1A) : An autosomal recessive, severe deficiency of growth hormone leading to dwarfism. Patients often develop antibodies to administered growth hormone. [The disease is caused by variants affecting the gene represented in this entry] | Growth hormone deficiency, isolated, 1B (IGHD1B) : An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy. [The disease is caused by variants affecting the gene represented in this entry] | Kowarski syndrome (KWKS) : A syndrome clinically characterized by short stature associated with bioinactive growth hormone, normal or slightly increased growth hormone secretion, pathologically low insulin-like growth factor 1 levels, and normal catch-up growth on growth hormone replacement therapy. [The disease is caused by variants affecting the gene represented in this entry] | Growth hormone deficiency, isolated, 2 (IGHD2) : An autosomal dominant deficiency of growth hormone leading to short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Monomer, dimer, trimer, tetramer and pentamer, disulfide-linked or non-covalently associated, in homomeric and heteromeric combinations. Can also form a complex either with GHBP or with the alpha2-macroglobulin complex

Gene: GH1  |  Organism: Homo sapiens  |  Synonyms: Growth hormone; Growth hormone 1; Pituitary growth hormone
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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