Recombinant Human Tescalcin (TESC), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 40.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Tescalcin (TESC)

Recombinant Human Tescalcin (TESC) — Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Purity >90%.

SKU: BCRECP-001758 Category:
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Product Specifications

Product SkuBCRECP-001758
Product DescriptionRecombinant Human Tescalcin (TESC) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 2-214aa. [Accession | Q96BS2].
Uniprot No.Q96BS2
Gene NamesTESC
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-214aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight40.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage.

Biological Context

Subcellular Location: Nucleus; Cytoplasm; Membrane (Lipid-anchor); Cell membrane; Cell projection, lamellipodium; Cell projection, ruffle membrane
Tissue Specificity: Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta

Product Specifications

Recombinant Human Tescalcin (TESC) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-214aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 40.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin

Subcellular Location

Nucleus; Cytoplasm; Membrane (Lipid-anchor); Cell membrane; Cell projection, lamellipodium; Cell projection, ruffle membrane

Tissue Specificity

Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta

Subunit

Monomer (By similarity). Homodimer; disulfide-linked (By similarity). Interacts with SLC9A1/NHE1; the interaction enables an optimal Na(+)/H(+) exchange activity (PubMed:11696366, PubMed:12809501, PubMed:18321853, PubMed:30287853)

Gene: TESC  |  Organism: Homo sapiens  |  Synonyms: Tescalcin
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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