Recombinant Human Thiamine transporter 2 (SLC19A3), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 11.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Thiamine transporter 2 (SLC19A3), partial

Recombinant Human Thiamine transporter 2 (SLC19A3), partial — Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Purity >90%.

SKU: BCRECP-001644 Category:
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Product Specifications

Product SkuBCRECP-001644
Product DescriptionRecombinant Human Thiamine transporter 2 (SLC19A3) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 208-273aa. [Accession | Q9BZV2].
Uniprot No.Q9BZV2
Gene NamesSLC19A3
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region208-273aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight11.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Mediates H(+)-dependent pyridoxine transport.

Biological Context

Subcellular Location: Membrane (Multi-pass membrane protein)
Tissue Specificity: Widely expressed but most abundant in placenta, kidney and liver
Disease Association: Basal ganglia disease, biotin-thiamine responsive (BTBGD) : An autosomal recessive metabolic disorder characterized by episodic encephalopathy, often triggered by febrile illness, presenting as confusion, seizures, external ophthalmoplegia, dysphagia, and sometimes coma and death. If untreated, encephalopathies can result in permanent dystonia. Brain imaging may show characteristic bilateral lesions of the basal ganglia. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Thiamine transporter 2 (SLC19A3), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 208-273aa, with N-terminal 6xHis-tagged tag, molecular weight 11.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism (PubMed:11731220, PubMed:33008889, PubMed:35512554, PubMed:35724964). Has no folate transport activity (PubMed:11731220). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, PubMed:35724964, PubMed:36456177)

Subcellular Location

Membrane (Multi-pass membrane protein)

Disease Association

Basal ganglia disease, biotin-thiamine responsive (BTBGD) : An autosomal recessive metabolic disorder characterized by episodic encephalopathy, often triggered by febrile illness, presenting as confusion, seizures, external ophthalmoplegia, dysphagia, and sometimes coma and death. If untreated, encephalopathies can result in permanent dystonia. Brain imaging may show characteristic bilateral lesions of the basal ganglia. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Widely expressed but most abundant in placenta, kidney and liver

Gene: SLC19A3  |  Organism: Homo sapiens  |  Synonyms: Solute carrier family 19 member 3
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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