Recombinant Human Thiamine transporter 2 (SLC19A3), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 11.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Thiamine transporter 2 (SLC19A3), partial

Recombinant Human Thiamine transporter 2 (SLC19A3), partial — Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Purity >90%.

SKU: BCRECP-001644 Category:
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Product Specifications

Product SkuBCRECP-001644
Product DescriptionRecombinant Human Thiamine transporter 2 (SLC19A3) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 208-273aa. [Accession | Q9BZV2].
Uniprot No.Q9BZV2
Gene NamesSLC19A3
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region208-273aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight11.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Mediates H(+)-dependent pyridoxine transport.

Biological Context

Subcellular Location: Membrane (Multi-pass membrane protein)
Tissue Specificity: Widely expressed but most abundant in placenta, kidney and liver
Disease Association: Basal ganglia disease, biotin-thiamine responsive (BTBGD) : An autosomal recessive metabolic disorder characterized by episodic encephalopathy, often triggered by febrile illness, presenting as confusion, seizures, external ophthalmoplegia, dysphagia, and sometimes coma and death. If untreated, encephalopathies can result in permanent dystonia. Brain imaging may show characteristic bilateral lesions of the basal ganglia. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Thiamine transporter 2 (SLC19A3), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 208-273aa, with N-terminal 6xHis-tagged tag, molecular weight 11.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism (PubMed:11731220, PubMed:33008889, PubMed:35512554, PubMed:35724964). Has no folate transport activity (PubMed:11731220). Mediates H(+)-dependent pyridoxine transport (PubMed:33008889, PubMed:35512554, PubMed:35724964, PubMed:36456177)

Subcellular Location

Membrane (Multi-pass membrane protein)

Disease Association

Basal ganglia disease, biotin-thiamine responsive (BTBGD) : An autosomal recessive metabolic disorder characterized by episodic encephalopathy, often triggered by febrile illness, presenting as confusion, seizures, external ophthalmoplegia, dysphagia, and sometimes coma and death. If untreated, encephalopathies can result in permanent dystonia. Brain imaging may show characteristic bilateral lesions of the basal ganglia. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Widely expressed but most abundant in placenta, kidney and liver

Gene: SLC19A3  |  Organism: Homo sapiens  |  Synonyms: Solute carrier family 19 member 3
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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