Recombinant Human TNF receptor-associated factor 5 (TRAF5), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 80.4kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human TNF receptor-associated factor 5 (TRAF5)

Recombinant Human TNF receptor-associated factor 5 (TRAF5) — Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Purity >90%.

SKU: BCRECP-001838 Categories: ,
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Product Specifications

Product SkuBCRECP-001838
Product DescriptionRecombinant Human TNF receptor-associated factor 5 (TRAF5) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-557aa. [Accession | O00463].
Uniprot No.O00463
Gene NamesTRAF5
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-557aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight80.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis.

Biological Context

Subcellular Location: Cytoplasm; Cytoplasm, cytosol
Tissue Specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood

Product Specifications

Recombinant Human TNF receptor-associated factor 5 (TRAF5) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-557aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 80.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR

Subcellular Location

Cytoplasm; Cytoplasm, cytosol

Tissue Specificity

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood

Subunit

Homotrimer (Probable). Heteromer with TRAF3. Associates with TNFRSF5/CD40 through interaction with TRAF3. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain)

Gene: TRAF5  |  Organism: Homo sapiens  |  Synonyms: RING finger protein 84
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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