Recombinant Human Transforming growth factor beta-3 (TGFB3)(Y340F), partial (Active), Homo sapiens (Human), Mammalian cell, Tag-Free, 12.7 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Transforming growth factor beta-3 (TGFB3)(Y340F), partial (Active)

Recombinant Human Transforming growth factor beta-3 (TGFB3)(Y340F), partial (Active) — Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. Purity >95%.

SKU: BCACP-001222 Categories: ,
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Product SKUBCACP-001222
Product DescriptionRecombinant Human Transforming growth factor beta-3 (TGFB3)(Y340F) protein is expressed from Mammalian cell with Tag-Free. It contains 301-412aa(Y340F). [Accession | P10600].
Uniprot No.P10600
Gene NamesTGFB3
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region301-412aa(Y340F)
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight12.7 kDa
ActivityThe ED50 as determined in a cell proliferation assay using TF?1 human erythroleukemic cells is less than 2 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesARVD; ARVD1; FLJ16571; LDS5; MGC105479; MGC118722; prepro-transforming growth factor beta-3; RNHF; TGF beta 3; TGF beta3; TGF-beta-3; TGFB 3; Tgfb3; TGFB3_HUMAN; transforming growth factor beta 3; Transforming growth factor beta-3

Function

Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus.

Biological Context

Subcellular Location: Secreted
Disease Association: Arrhythmogenic right ventricular dysplasia, familial, 1 (ARVD1) : A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. [The disease is caused by variants affecting the gene represented in this entry] | Loeys-Dietz syndrome 5 (LDS5) : A form of Loeys-Dietz syndrome, a syndrome with widespread systemic involvement characterized by arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. LDS5 additional variable features include mitral valve disease, skeletal overgrowth, cervical spine instability, and clubfoot deformity. LDS5 patients do not manifest remarkable aortic or arterial tortuosity, and there is no strong evidence for early aortic dissection. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Transforming growth factor beta-3 (TGFB3)(Y340F), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 301-412aa(Y340F), with Tag-Free tag, molecular weight 12.7 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: The ED50 as determined in a cell proliferation assay using TF?1 human erythroleukemic cells is less than 2 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)

Subcellular Location

Secreted

Disease Association

Arrhythmogenic right ventricular dysplasia, familial, 1 (ARVD1) : A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias. [The disease is caused by variants affecting the gene represented in this entry] | Loeys-Dietz syndrome 5 (LDS5) : A form of Loeys-Dietz syndrome, a syndrome with widespread systemic involvement characterized by arterial tortuosity and aneurysms, hypertelorism, and bifid uvula or cleft palate. LDS5 additional variable features include mitral valve disease, skeletal overgrowth, cervical spine instability, and clubfoot deformity. LDS5 patients do not manifest remarkable aortic or arterial tortuosity, and there is no strong evidence for early aortic dissection. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Interacts with ASPN (PubMed:8819159). Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide: Interacts with Transforming growth factor beta-3 (TGF-beta-3) chain; interaction is non-covalent and maintains (TGF-beta-3) in a latent state (By similarity). Latency-associated peptide: Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-3 and promote epithelial fusion during palate development (By similarity). Latency-associated peptide: Interacts (via cell attachment site) with integrins, leading to release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Homodimer; disulfide-linked (PubMed:8819159). Transforming growth factor beta-3: Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity)

Gene: TGFB3  |  Organism: Homo sapiens

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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