Recombinant Human Transient receptor potential cation channel subfamily V member 3 (TRPV3) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-Flag-tagged, 93.1kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Transient receptor potential cation channel subfamily V member 3 (TRPV3) Protein

Recombinant Human Transient receptor potential cation channel subfamily V member 3 (TRPV3) Protein — Non-selective calcium permeant cation channel. Purity >85%.

SKU: BCRECP-00180TM Category:
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Product Specifications

Uniprot No.Q8NET8
Gene NamesTRPV3
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-790aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-Flag-tagged
Molecular weight93.1kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein); Cytoplasm; Lysosome
Tissue Specificity: Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level)
Disease Association: Olmsted syndrome 1 (OLMS1) : An autosomal dominant, rare congenital disorder characterized by bilateral mutilating palmoplantar keratoderma and periorificial keratotic plaques with severe itching at all lesions. Diffuse alopecia, constriction of digits, and onychodystrophy have also been reported. Infections and squamous cell carcinomas can arise on the keratotic areas. The digital constriction may progress to autoamputation of fingers and toes. [The disease is caused by variants affecting the gene represented in this entry] | Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2) : A dermatological disorder characterized by non-epidermolytic, abnormal thickening of the skin on the palms and soles. Focal palmoplantar keratoderma consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Transient receptor potential cation channel subfamily V member 3 (TRPV3) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-790aa, with N-terminal 10xHis-Flag-tagged tag, molecular weight 93.1kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Non-selective calcium permeant cation channel (PubMed:12077604, PubMed:12077606, PubMed:26818531, PubMed:37648856, PubMed:38691614). It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius (PubMed:12077604, PubMed:12077606). Activation exhibits an outward rectification (PubMed:12077604). The channel pore can dilate to provide permeability to larger cations (PubMed:37648856). May associate with TRPV1 and may modulate its activity (PubMed:12077606). Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (PubMed:21593771)

Subcellular Location

Cell membrane (Multi-pass membrane protein); Cytoplasm; Lysosome

Disease Association

Olmsted syndrome 1 (OLMS1) : An autosomal dominant, rare congenital disorder characterized by bilateral mutilating palmoplantar keratoderma and periorificial keratotic plaques with severe itching at all lesions. Diffuse alopecia, constriction of digits, and onychodystrophy have also been reported. Infections and squamous cell carcinomas can arise on the keratotic areas. The digital constriction may progress to autoamputation of fingers and toes. [The disease is caused by variants affecting the gene represented in this entry] | Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2) : A dermatological disorder characterized by non-epidermolytic, abnormal thickening of the skin on the palms and soles. Focal palmoplantar keratoderma consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion (at protein level). Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles (at protein level)

Subunit

Homotetramer (PubMed:37648856, PubMed:38691614). May convert from a homotetramer to a homopentamer to allow pore dilation (PubMed:37648856). Interacts with TRPV1; may form a heteromeric channel with TRPV1 (PubMed:12077606). Interacts with SNX11; this interaction promotes TRPV3 trafficking from the cell membrane to lysosome for degradation (PubMed:26818531)

Gene: TRPV3  |  Organism: Homo sapiens  |  Synonyms: Vanilloid receptor-like 3
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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