Recombinant Human tRNA (adenine (58)-N (1))-methyltransferase catalytic subunit TRMT61A (TRMT61A), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 35.5kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human tRNA (adenine (58)-N (1))-methyltransferase catalytic subunit TRMT61A (TRMT61A)

Recombinant Human tRNA (adenine (58)-N (1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) — Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Purity >95%.

SKU: BCRECP-001858 Categories: ,
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Product Specifications

Product SkuBCRECP-001858
Product DescriptionRecombinant Human tRNA (adenine (58)-N (1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 1-289aa. [Accession | Q96FX7].
Uniprot No.Q96FX7
Gene NamesTRMT61A
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-289aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight35.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries.

Biological Context

Subcellular Location: Nucleus

Product Specifications

Recombinant Human tRNA (adenine (58)-N (1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-289aa, with N-terminal 6xHis-tagged tag, molecular weight 35.5kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29072297, PubMed:29107537)

Subcellular Location

Nucleus

Subunit

Heterotetramer; composed of two copies of TRMT6 and two copies of TRMT61A

Gene: TRMT61A  |  Organism: Homo sapiens  |  Synonyms: mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A; tRNA(m1A58)-methyltransferase subunit TRMT61A
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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