Recombinant Human Tumor necrosis factor ligand superfamily member 14 (TNFSF14), partial,Biotinylated (Active), Homo sapiens (Human), Mammalian cell, N-terminal hFc-Avi-tagged, 47.3 kDa, purity >90% as determined by SDS-PAGE.
, , ,

Recombinant Human Tumor necrosis factor ligand superfamily member 14 (TNFSF14), partial,Biotinylated (Active)

Recombinant Human Tumor necrosis factor ligand superfamily member 14 (TNFSF14), partial,Biotinylated (Active) — Cytokine that binds to TNFRSF3/LTB and TNFRSF14/HVEM and plays major roles in immune system regulation. Purity >90%.

SKU: BCACP-000107 Categories: , , ,
Online Inquiry →
Product SKUBCACP-000107
Product DescriptionRecombinant Human Tumor necrosis factor ligand superfamily member 14 (TNFSF14), Biotinylated protein is expressed from Mammalian cell with N-terminal hFc-Avi-tagged. It contains 74-240aa. [Accession | O43557].
Uniprot No.O43557
Gene NamesTNFSF14
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region74-240aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal hFc-Avi-tagged
Molecular weight47.3 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized KLRK1 at 10 μg/ml can bind human Biotinylated ULBP1, the EC50 is 4.254-7.295 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesTNFSF14; HVEML; LIGHT; UNQ391/PRO726; Tumor necrosis factor ligand superfamily member 14; Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand; CD antigen CD258

Function

Cytokine that binds to TNFRSF3/LTB and TNFRSF14/HVEM and plays major roles in immune system regulation. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production. Binds to the decoy receptor TNFRSF6B thereby disrupts the activation signal initiated by TNFSF14, resulting in reduced T-cell activation.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines

Product Specifications

Recombinant Human Tumor necrosis factor ligand superfamily member 14 (TNFSF14), partial,Biotinylated (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 74-240aa, with N-terminal hFc-Avi-tagged tag, molecular weight 47.3 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized KLRK1 at 10 μg/ml can bind human Biotinylated ULBP1, the EC50 is 4.254-7.295 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Cytokine that binds to TNFRSF3/LTB and TNFRSF14/HVEM and plays major roles in immune system regulation (PubMed:10754304, PubMed:9462508). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304). Binds to the decoy receptor TNFRSF6B thereby disrupts the activation signal initiated by TNFSF14, resulting in reduced T-cell activation (PubMed:25087510)

Subcellular Location

Cytoplasm

Tissue Specificity

Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines

Subunit

Homotrimer. TNFSF14 binds to TNFRSF6B with 3:3 stoichiometry (PubMed:25087510). Interacts with TNFRSF14

Gene: TNFSF14  |  Organism: Homo sapiens  |  Synonyms: Herpes virus entry mediator ligand
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

Shopping Cart
Scroll to Top