Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15), partial (Active), Homo sapiens (Human), E.Coli, Tag-Free, 20.5 kDa, purity >>97% as determined by SDS-PAGE.
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Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15), partial (Active)

Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15), partial (Active) — Cytokine that signals through TNFRSF25 receptor. Purity >97%.

SKU: BCACP-000968 Categories: ,
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Product SKUBCACP-000968
Product DescriptionRecombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15) protein is expressed from E.Coli with Tag-Free. It contains 72-251aa. [Accession | O95150].
Uniprot No.O95150
Gene NamesTNFSF15
Purity>97% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region72-251aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight20.5 kDa
ActivityFully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 cells is less than 0.2 μg/ml, corresponding to a specific activity of >5000 IU/mg in the presence of 0.25 ng/mL of rHuTNF-α.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesTNFSF15; TL1; VEGI; Tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor

Function

Cytokine that signals through TNFRSF25 receptor. Functions as a T-cell costimulator, that increases IL-2 responsiveness and secretion of proinflammatory cytokines which enhances T-cell activation, proliferation and the survival of activated T-cells.

Product Specifications

Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15), partial (Active) — Cytokine that signals through TNFRSF25 receptor. Purity >97%. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Cytokine that signals through TNFRSF25 receptor (PubMed:11911831). Functions as a T-cell costimulator, that increases IL-2 responsiveness and secretion of proinflammatory cytokines which enhances T-cell activation, proliferation and the survival of activated T-cells (PubMed:10597252, PubMed:11911831). Inhibits vascular endothelial growth and angiogenesis (in vitro) (PubMed:11923219, PubMed:9872942). Binds to the decoy receptor TNFRSF6B, blocking the activation normally triggered by TNFSF15 and leading to decreased T-cell activation and reduced inflammation (PubMed:21300286)

Subcellular Location

Secreted

Tissue Specificity

Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon

Subunit

Homotrimer (PubMed:17935696). TNFSF15 binds TNFRSF6B with 3:3 stoichiometry (PubMed:21300286)

Gene: TNFSF15  |  Organism: Homo sapiens  |  Synonyms: TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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