Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial (Active), Homo sapiens (Human), Mammalian cell, N-terminal 6xHis-tagged, 16.3 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial (Active)

Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial (Active) — Cytokine that binds to TNFRSF4. Purity >95%.

SKU: BCACP-001282 Categories: ,
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Product SKUBCACP-001282
Product DescriptionRecombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4) protein is expressed from Mammalian cell with N-terminal 6xHis-tagged. It contains 51-183aa. [Accession | P23510].
Uniprot No.P23510
Gene NamesTNFSF4
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region51-183aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight16.3 kDa
ActivityThe ED50 as determined by its ability to bind Mouse TNFSF4 in functional ELISA is less than 2 ug/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesTNFSF4; TXGP1; Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD antigen CD252

Function

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

Biological Context

Subcellular Location: Membrane (Single-pass type II membrane protein)
Disease Association: Systemic lupus erythematosus (SLE) : A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. [Disease susceptibility is associated with variants affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance]

Product Specifications

Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 51-183aa, with N-terminal 6xHis-tagged tag, molecular weight 16.3 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production

Subcellular Location

Membrane (Single-pass type II membrane protein)

Disease Association

Systemic lupus erythematosus (SLE) : A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. [Disease susceptibility is associated with variants affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance]

Subunit

Homotrimer

Gene: TNFSF4  |  Organism: Homo sapiens  |  Synonyms: Glycoprotein Gp34; OX40 ligand; TAX transcriptionally-activated glycoprotein 1
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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