Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 53.4kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5)

Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) — Protease that specifically cleaves ‘Lys-48’-linked polyubiquitin chains. Purity >90%.

SKU: BCRECP-001888 Categories: ,
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Product Specifications

Product SkuBCRECP-001888
Product DescriptionRecombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-326aa. [Accession | Q9Y5K5].
Uniprot No.Q9Y5K5
Gene NamesUCHL5
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-326aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight53.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Biological Context

Subcellular Location: Cytoplasm; Nucleus

Product Specifications

Recombinant Human Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-326aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 53.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1

Subcellular Location

Cytoplasm; Nucleus

Subunit

Component of the 19S (PA700) regulatory complex of the 26S proteasome. Interacts with ADRM1 and NFRKB; in vitro ADRM1 and NFRKB compete for interaction with UCHL5. Component of the INO80 complex; specifically part of a complex module associated with N-terminus of INO80

Gene: UCHL5  |  Organism: Homo sapiens  |  Synonyms: Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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