Recombinant Human Valacyclovir hydrolase (BPHL), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged and C-terminal Myc-tagged, 32.3kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Valacyclovir hydrolase (BPHL)

Recombinant Human Valacyclovir hydrolase (BPHL) — Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a pr… Purity >90%.

SKU: BCRECP-000173 Categories: ,
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Product Specifications

Product SkuBCRECP-000173
Product DescriptionRecombinant Human Valacyclovir hydrolase (BPHL) Protein is expressed from Yeast with N-terminal 6xHis-tagged and C-terminal Myc-tagged. It contains 38-291aa. [Accession | Q86WA6].
Uniprot No.Q86WA6
Gene NamesBPHL
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region38-291aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged and C-terminal Myc-tagged
Molecular weight32.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Has homocysteine-thiolactonase activity (in vitro) and may play a significant role in the detoxification of homocysteine thiolactone in vivo. Catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir, converting them into their active forms (acyclovir and ganciclovir).

Biological Context

Subcellular Location: Mitochondrion
Tissue Specificity: Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle

Product Specifications

Recombinant Human Valacyclovir hydrolase (BPHL) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 38-291aa, with N-terminal 6xHis-tagged and C-terminal Myc-tagged tag, molecular weight 32.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol (PubMed:12732646, PubMed:15832508, PubMed:18256025, PubMed:25333274, PubMed:32196348). Has homocysteine-thiolactonase activity (in vitro) and may play a significant role in the detoxification of homocysteine thiolactone in vivo (PubMed:25333274). Catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir, converting them into their active forms (acyclovir and ganciclovir) (PubMed:15832508, PubMed:18256025)

Subcellular Location

Mitochondrion

Tissue Specificity

Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle

Subunit

Monomer. May also form homodimers

Gene: BPHL  |  Organism: Homo sapiens  |  Synonyms: Biphenyl hydrolase-like protein; Biphenyl hydrolase-related protein; Breast epithelial mucin-associated antigen; L-homocysteine-thiolactonase BPHL; Valacyclovir hydrolase
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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