Recombinant JC polyomavirus Small t antigen, JC polyomavirus (JCPyV) (JCV), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 27.7kDa, purity >85% as determined by SDS-PAGE.
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Recombinant JC polyomavirus Small t antigen

Recombinant JC polyomavirus Small t antigen — Promotes efficient viral genome replication by modulating several host signaling pathways including transport network, interferon production or cell cycle progression. Purity >85%.

SKU: BCRECP-003658 Categories: ,
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Product Specifications

Product SkuBCRECP-003658
Product DescriptionRecombinant JC polyomavirus Small t antigen Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-172aa. [Accession | P03083].
Uniprot No.P03083
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-172aa
SpeciesJC polyomavirus (JCPyV) (JCV)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight27.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Promotes efficient viral genome replication by modulating several host signaling pathways including transport network, interferon production or cell cycle progression. Inhibits host PP2A phosphatase activity and thereby prevents agnoprotein dephosphorylation. Inactivation of PP2A also results in the transactivation of cyclin A and cyclin D1 promoters.

Biological Context

Subcellular Location: Host cytoplasm; Host nucleus

Product Specifications

Recombinant JC polyomavirus Small t antigen is a recombinant protein from JC polyomavirus (JCPyV) (JCV), expressed in E.coli, covering amino acids 1-172aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 27.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Promotes efficient viral genome replication by modulating several host signaling pathways including transport network, interferon production or cell cycle progression (PubMed:20485545, PubMed:33092197, PubMed:33849980). Inhibits host PP2A phosphatase activity and thereby prevents agnoprotein dephosphorylation (PubMed:18353419, PubMed:20485545). Inactivation of PP2A also results in the transactivation of cyclin A and cyclin D1 promoters (By similarity). In addition, antagonizes the RIGI-mediated IFN response through interaction with E3 ligase TRIM25 leading to the inhibition of 'Lys-63'-linked ubiquitination of RIGI. Inhibits nucleotide excision repair (NER) pathway which leads to DNA strand breaks during DNA replication and micronuclei formation (PubMed:25744060)

Subcellular Location

Host cytoplasm; Host nucleus

Subunit

Interacts with host PPP2R1A; the interaction inhibits PP2A activity (PubMed:20485545). Interacts with agnoprotein; this interaction prevents agnoprotein dephosphorylation by host PP2A (PubMed:18353419). Interacts with host RBL1 and RBL2 (PubMed:20485545). Interacts with SMARCA5 (PubMed:33092197). Interacts with SDHB (PubMed:33092197)

Organism: JC polyomavirus
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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