Recombinant Macaca fascicularis B- and T-lymphocyte attenuator (BTLA), partial (Active), Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey), Mammalian cell, C-terminal 10xHis-tagged, 15.3 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Macaca fascicularis B- and T-lymphocyte attenuator (BTLA), partial (Active)

Recombinant Macaca fascicularis B- and T-lymphocyte attenuator (BTLA), partial (Active) — Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. Purity >95%.

SKU: BCACP-000422 Category:
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Product SKUBCACP-000422
Product DescriptionRecombinant Cynomolgus monkey B- and T-lymphocyte attenuator (BTLA) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 31-152aa. [Accession | A0A2K5W7M7].
Uniprot No.A0A2K5W7M7
Gene NamesBTLA
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region31-152aa
SpeciesMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Tag InfoC-terminal 10xHis-tagged
Molecular weight15.3 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Macaca mulatta TNFSF15 at 2 μg/mL can bind Anti-HSPA5 recombinant antibody . The EC50 is 0.9216-1.128 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesB- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA

Function

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14.

Product Specifications

Recombinant Macaca fascicularis B- and T-lymphocyte attenuator (BTLA), partial (Active) — Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. Purity >95%. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca mulatta TNFSF15 at 2 μg/mL can bind Anti-HSPA5 recombinant antibody . The EC50 is 0.9216-1.128 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Subunit

Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM (via cysteine-rich domain 1)

Organism: Macaca fascicularis  |  Synonyms: B- and T-lymphocyte-associated protein

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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