Recombinant Measles virus Fusion glycoprotein F0 (F) Protein, Measles virus (strain Leningrad-16) (MeV) (Subacute sclerose panencephalitis virus), in vitro E.coli expression system, N-terminal 10xHis-tagged and C-terminal Avi-tagged, 61.8kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Measles virus Fusion glycoprotein F0 (F) Protein

Recombinant Measles virus Fusion glycoprotein F0 (F) Protein — Some hyperfusogenic isolates can induce membrane fusion in SLAM- and nectin-4-negative cells and are linked to fatal subacute sclerosing panencephalitis (SSPE) or measles inclusion body encephaliti… Purity >85%.

SKU: BCRECP-00282TM Categories: , ,
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Product Specifications

Uniprot No.P69356
Gene NamesF
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region24-550aa
SpeciesMeasles virus (strain Leningrad-16) (MeV) (Subacute sclerose panencephalitis virus)
Tag InfoN-terminal 10xHis-tagged and C-terminal Avi-tagged
Molecular weight61.8kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Some hyperfusogenic isolates can induce membrane fusion in SLAM- and nectin-4-negative cells and are linked to fatal subacute sclerosing panencephalitis (SSPE) or measles inclusion body encephalitis (MIBE). The neuropathogenicity is closely associated with enhanced propagation mediated by cell-to-cell fusion in the brain, which is principally regulated by hyperfusogenic mutations of the viral F protein. Cell-to-cell transmission of the virus also occurs with hyperfusogenic isolates.

Biological Context

Subcellular Location: Virion membrane (Single-pass type I membrane protein); Host cell membrane (Single-pass membrane protein)

Product Specifications

Recombinant Measles virus Fusion glycoprotein F0 (F) Protein is a recombinant protein from Measles virus (strain Leningrad-16) (MeV) (Subacute sclerose panencephalitis virus), expressed in in vitro E.coli expression system, covering amino acids 24-550aa, with N-terminal 10xHis-tagged and C-terminal Avi-tagged tag, molecular weight 61.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Some hyperfusogenic isolates can induce membrane fusion in SLAM- and nectin-4-negative cells and are linked to fatal subacute sclerosing panencephalitis (SSPE) or measles inclusion body encephalitis (MIBE). The neuropathogenicity is closely associated with enhanced propagation mediated by cell-to-cell fusion in the brain, which is principally regulated by hyperfusogenic mutations of the viral F protein. Cell-to-cell transmission of the virus also occurs with hyperfusogenic isolates

Subcellular Location

Virion membrane (Single-pass type I membrane protein); Host cell membrane (Single-pass membrane protein)

Subunit

Homotrimer of disulfide-linked F1-F2

Gene: F  |  Organism: Measles virus (strain Leningrad-16)

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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