Recombinant Mesocricetus auratus CD27 antigen (Cd27), partial, Mesocricetus auratus (Golden hamster), E.coli, N-terminal 6xHis-tagged and C-terminal Strep II-tagged, 20.5kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Mesocricetus auratus CD27 antigen (Cd27), partial

Recombinant Mesocricetus auratus CD27 antigen (Cd27), partial — Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. Purity >90%.

SKU: BCRECP-002315 Categories: ,
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Product Specifications

Product SkuBCRECP-002315
Product DescriptionRecombinant Mesocricetus auratus CD27 antigen (Cd27) Protein is expressed from E.coli with N-terminal 6xHis-tagged and C-terminal Strep II-tagged. It contains 21-187aa. [Accession | A0A3Q0DDP5].
Uniprot No.A0A3Q0DDP5
Gene NamesCd27
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region21-187aa
SpeciesMesocricetus auratus (Golden hamster)
Tag InfoN-terminal 6xHis-tagged and C-terminal Strep II-tagged
Molecular weight20.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)

Product Specifications

Recombinant Mesocricetus auratus CD27 antigen (Cd27), partial is a recombinant protein from Mesocricetus auratus (Golden hamster), expressed in E.coli, covering amino acids 21-187aa, with N-terminal 6xHis-tagged and C-terminal Strep II-tagged tag, molecular weight 20.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Subunit

Homodimer. Interacts with SIVA1; may play a role in apoptosis through association with SIVA1. Interacts with TRAF2. Interacts ith PTPN6

Gene: Cd27  |  Organism: Mesocricetus auratus  |  Synonyms: CD27L receptor; T-cell activation antigen CD27; Tumor necrosis factor receptor superfamily member 7

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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