Recombinant Mouse C-C chemokine receptor type 1 (Ccr1) Protein

Function

Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:9166425). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (By similarity). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4 (PubMed:15831559). Also mediates monocyte migration upon CXCL4 binding (By similarity). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (PubMed:31898284)

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Tissue Specificity

Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes

Subunit

Interacts with CREB3. Interacts with CCL3. Interacts with CCL15. Interacts with CCL23. Interacts with GNAI1. Interacts with PF4/CXCL4

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• Ramos C.D. et al. MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4. — J. Leukoc. Biol. (2005)
• Yan J. et al. CCR1 Activation Promotes Neuroinflammation Through CCR1/TPR1/ERK1/2 Signaling Pathway After Intracerebral Hemorrhage in Mice. — Neurotherapeutics (2020)