Recombinant Mouse Desmocollin-3 (Dsc3) Protein, Mus musculus (Mouse), in vitro E.coli expression system, N-terminal 10xHis-tagged, 86.3kDa, purity >85% as determined by SDS-PAGE.

Recombinant Mouse Desmocollin-3 (Dsc3) Protein

Recombinant Mouse Desmocollin-3 (Dsc3) Protein — A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Purity >85%.

SKU: BCRECP-00283TM Category:
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Product Specifications

Uniprot No.P55850
Gene NamesDsc3
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region136-896aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 10xHis-tagged
Molecular weight86.3kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function. Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Cell junction, desmosome; Cytoplasm
Tissue Specificity: Expressed in the basal layers of epidermal stratified epithelia from birth (at protein level)

Product Specifications

Recombinant Mouse Desmocollin-3 (Dsc3) Protein is a recombinant protein from Mus musculus (Mouse), expressed in in vitro E.coli expression system, covering amino acids 136-896aa, with N-terminal 10xHis-tagged tag, molecular weight 86.3kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not Test

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:38395410). Required for cell-cell adhesion in the epidermis, as a result required for the maintenance of the dermal cohesion and the dermal barrier function (PubMed:18682494). Required for cell-cell adhesion of epithelial cell layers surrounding the telogen hair club, as a result plays an important role in telogen hair shaft anchorage (PubMed:18682494). Essential for successful completion of embryo compaction and development beyond the 8-cell stage (PubMed:16418220)

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Cell junction, desmosome; Cytoplasm

Tissue Specificity

Expressed in the basal layers of epidermal stratified epithelia from birth (at protein level)

Subunit

May form homodimers (By similarity). Interacts with DSG1; there is evidence to suggest that the interaction promotes cell-cell adhesion of keratinocytes (By similarity)

Gene: Dsc3  |  Organism: Mus musculus
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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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