Recombinant Mouse Eotaxin protein (Ccl11), Mus musculus (Mouse), E.Coli, Tag-Free, 8.4 kDa, purity >>96% as determined by SDS-PAGE.
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Recombinant Mouse Eotaxin protein (Ccl11)

Recombinant Mouse Eotaxin protein (Ccl11) — Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and… Purity >96%.

SKU: BCACP-000803 Categories: ,
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Product SKUBCACP-000803
Product DescriptionRecombinant Mouse Eotaxin protein (Ccl11) protein is expressed from E.Coli with Tag-Free. It contains 24-97aa. [Accession | P48298].
Uniprot No.P48298
Gene NamesCcl11
Purity>96% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region24-97aa
SpeciesMus musculus (Mouse)
Tag InfoTag-Free
Molecular weight8.4 kDa
ActivityFully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human mature dendritic cells is in a concentration range of 10-100 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesCcl11; Scya11Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11

Function

Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells. Exerts its effects primarily by binding to the CCR3 receptor. Induces also chemotaxis of endothelial cells and promotes angiogenesis by activating the PI3K/Akt pathway.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney

Product Specifications

Recombinant Mouse Eotaxin protein (Ccl11) is a recombinant protein from Mus musculus (Mouse), expressed in E.Coli, covering amino acids 24-97aa, with Tag-Free tag, molecular weight 8.4 kDa, purity >96% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human mature dendritic cells is in a concentration range of 10-100 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells (PubMed:7568052, PubMed:8574847). Exerts its effects primarily by binding to the CCR3 receptor. Induces also chemotaxis of endothelial cells and promotes angiogenesis by activating the PI3K/Akt pathway

Subcellular Location

Secreted

Tissue Specificity

Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney

Gene: Ccl11  |  Organism: Mus musculus  |  Synonyms: C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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