Recombinant Mouse Erythropoietin receptor (Epor), partial — Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Purity >90%.
| Product Sku | BCRECP-002645 |
| Product Description | Recombinant Mouse Erythropoietin receptor (Epor) Protein is expressed from Baculovirus with C-terminal 10xHis-tagged. It contains 25-249aa. [Accession | P14753]. |
| Uniprot No. | P14753 |
| Gene Names | Epor |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Expression System | Baculovirus |
| Expression Region | 25-249aa |
| Species | Mus musculus (Mouse) |
| Tag Info | C-terminal 10xHis-tagged |
| Molecular weight | 26.3kDa |
| Activity | Please contact us to obtain bioactivity data. |
| Buffer | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose. |
| Storage | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Research Areas | Cardiovascular |
Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade.
Recombinant Mouse Erythropoietin receptor (Epor), partial — Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Purity >90%. Suitable for ELISA and Western Blot applications.
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Please contact us to obtain bioactivity data.
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (PubMed:2539263, PubMed:8341708, PubMed:8382775, PubMed:8617735). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (PubMed:2539263, PubMed:8382775, PubMed:8617735). In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase (PubMed:9573010)
Secreted
Expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells
(Microbial infection) Interacts with friend spleen focus-forming virus protein GP55, leading to ligand-independent activation of EPOR and to the abnormally rapid proliferation of erythroid precursor cells
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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.
Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.
Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.
