Recombinant Mouse Erythropoietin receptor (Epor), partial — Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Purity >90%.
| Product Sku | BCRECP-002645 |
| Product Description | Recombinant Mouse Erythropoietin receptor (Epor) Protein is expressed from Baculovirus with C-terminal 10xHis-tagged. It contains 25-249aa. [Accession | P14753]. |
| Uniprot No. | P14753 |
| Gene Names | Epor |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Expression System | Baculovirus |
| Expression Region | 25-249aa |
| Species | Mus musculus (Mouse) |
| Tag Info | C-terminal 10xHis-tagged |
| Molecular weight | 26.3kDa |
| Activity | Please contact us to obtain bioactivity data. |
| Buffer | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose. |
| Storage | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Research Areas | Cardiovascular |
Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade.
Recombinant Mouse Erythropoietin receptor (Epor), partial — Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation. Purity >90%. Suitable for ELISA and Western Blot applications.
SDS-PAGE: Single band at expected molecular weight confirming purity.
ELISA: Suitable as coating antigen or detection standard.
Western Blot: Compatible with standard Western Blot protocols.
Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.
Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.
Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.
Shelf Life: 12 months from date of receipt when stored as recommended.
Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.
Receptor for erythropoietin, which mediates erythropoietin-induced erythroblast proliferation and differentiation (PubMed:2539263, PubMed:8341708, PubMed:8382775, PubMed:8617735). Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (PubMed:2539263, PubMed:8382775, PubMed:8617735). In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase (PubMed:9573010)
Secreted
Expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells
(Microbial infection) Interacts with friend spleen focus-forming virus protein GP55, leading to ligand-independent activation of EPOR and to the abnormally rapid proliferation of erythroid precursor cells
Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.
Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.
Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.
Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.
