Recombinant Mouse Hepcidin (Hamp), partial

Recombinant Mouse Hepcidin (Hamp), partial — Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Purity >90%.

SKU: BCRECP-002967 Category:

Product Specifications

Product SkuBCRECP-002967
Product DescriptionRecombinant Mouse Hepcidin (Hamp) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 59-83aa. [Accession | Q9EQ21].
Uniprot No.Q9EQ21
Gene NamesHamp
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region59-83aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal GST-tagged
Molecular weight29.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Highly expressed in the liver and to a much lesser extent in the heart. Secreted in blood

Product Specifications

Recombinant Mouse Hepcidin (Hamp), partial is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 59-83aa, with N-terminal GST-tagged tag, molecular weight 29.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Protein Biology

Function

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes

Subcellular Location

Secreted

Tissue Specificity

Highly expressed in the liver and to a much lesser extent in the heart. Secreted in blood (PubMed:15124018)

Subunit

Interacts with SLC40A1; this interaction promotes SLC40A1 rapid ubiquitination

Gene: Hamp  |  Organism: Mus musculus
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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