Recombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2), partial (Active), Mus musculus (Mouse), Mammalian cell, C-terminal 10xHis-tagged, 37.4 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2), partial (Active)

Recombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2), partial (Active) — Receptor for interleukin-36 (IL36A, IL36B and IL36G). Purity >95%.

SKU: BCACP-000647 Categories: ,
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Product SKUBCACP-000647
Product DescriptionRecombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 22-338aa. [Accession | Q9ERS7].
Uniprot No.Q9ERS7
Gene NamesIl1rl2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region22-338aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 10xHis-tagged
Molecular weight37.4 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human SELE at 2 μg/mL can bind Anti-SELE recombinant antibody . The EC50 is 0.4369-0.5030 ng/mL.;SELE Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human SELE with an affinity constant of 1.41 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInterleukin-1 receptor-like 2; EC 3.2.2.6; IL-36 receptor; Interleukin-1 receptor-related protein 2; IL-1Rrp2; IL1R-rp2

Function

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein)
Tissue Specificity: Expressed in bone marrow-derived dendritic cells, splenic CD4(+) T-cells, bone marrow-derived macrophages and bone marrow-derived neutrophils

Product Specifications

Recombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2), partial (Active) is a recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell, covering amino acids 22-338aa, with C-terminal 10xHis-tagged tag, molecular weight 37.4 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway

Subcellular Location

Membrane (Single-pass type I membrane protein)

Tissue Specificity

Expressed in bone marrow-derived dendritic cells, splenic CD4(+) T-cells, bone marrow-derived macrophages and bone marrow-derived neutrophils

Subunit

Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN

Gene: Il1rl2  |  Organism: Mus musculus  |  Synonyms: IL-36 receptor; Interleukin-1 receptor-related protein 2

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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