Recombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2), partial (Active), Mus musculus (Mouse), Mammalian cell, C-terminal 10xHis-tagged, 37.4 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2), partial (Active)

Recombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2), partial (Active) — Receptor for interleukin-36 (IL36A, IL36B and IL36G). Purity >95%.

SKU: BCACP-000647 Categories: ,
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Product SKUBCACP-000647
Product DescriptionRecombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 22-338aa. [Accession | Q9ERS7].
Uniprot No.Q9ERS7
Gene NamesIl1rl2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region22-338aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 10xHis-tagged
Molecular weight37.4 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human SELE at 2 μg/mL can bind Anti-SELE recombinant antibody . The EC50 is 0.4369-0.5030 ng/mL.;SELE Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human SELE with an affinity constant of 1.41 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInterleukin-1 receptor-like 2; EC 3.2.2.6; IL-36 receptor; Interleukin-1 receptor-related protein 2; IL-1Rrp2; IL1R-rp2

Function

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system.

Biological Context

Subcellular Location: Membrane (Single-pass type I membrane protein)
Tissue Specificity: Expressed in bone marrow-derived dendritic cells, splenic CD4(+) T-cells, bone marrow-derived macrophages and bone marrow-derived neutrophils

Product Specifications

Recombinant Mouse Interleukin-1 receptor-like 2 (Il1rl2), partial (Active) is a recombinant protein from Mus musculus (Mouse), expressed in Mammalian cell, covering amino acids 22-338aa, with C-terminal 10xHis-tagged tag, molecular weight 37.4 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SELE at 2 μg/mL can bind Anti-SELE recombinant antibody . The EC50 is 0.4369-0.5030 ng/mL.;SELE Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human SELE with an affinity constant of 1.41 nM as detected by MetaSPR Assay (WeSPRTM 200).

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway

Subcellular Location

Membrane (Single-pass type I membrane protein)

Tissue Specificity

Expressed in bone marrow-derived dendritic cells, splenic CD4(+) T-cells, bone marrow-derived macrophages and bone marrow-derived neutrophils

Subunit

Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN

Gene: Il1rl2  |  Organism: Mus musculus  |  Synonyms: IL-36 receptor; Interleukin-1 receptor-related protein 2

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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