Recombinant Mouse Interleukin-33 protein (Il33), partial (Active), Mus musculus (Mouse), E.Coli, Tag-Free, 17.5 kDa, purity >>98% as determined by SDS-PAGE.
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Recombinant Mouse Interleukin-33 protein (Il33), partial (Active)

Recombinant Mouse Interleukin-33 protein (Il33), partial (Active) — In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester … Purity >98%.

SKU: BCACP-000725 Categories: ,
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Product SKUBCACP-000725
Product DescriptionRecombinant Mouse Interleukin-33 protein (Il33) protein is expressed from E.Coli with Tag-Free. It contains 109-266aa. [Accession | Q8BVZ5].
Uniprot No.Q8BVZ5
Gene NamesIl33
Purity>98% as determined by SDS-PAGE.
Expression SystemE.Coli
Expression Region109-266aa
SpeciesMus musculus (Mouse)
Tag InfoTag-Free
Molecular weight17.5 kDa
ActivityFully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 20 pg/ml, corresponding to a specific activity of >5.0x107 IU/mg.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesIl33Interleukin-33; IL-33) [Cleaved into: Interleukin-33(102-266); Interleukin-33(109-266)]

Function

In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation.

Biological Context

Subcellular Location: Nucleus

Product Specifications

Recombinant Mouse Interleukin-33 protein (Il33), partial (Active) is a recombinant protein from Mus musculus (Mouse), expressed in E.Coli, covering amino acids 109-266aa, with Tag-Free tag, molecular weight 17.5 kDa, purity >98% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 20 pg/ml, corresponding to a specific activity of >5.0x107 IU/mg.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (By similarity). This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity)

Subcellular Location

Nucleus

Subunit

Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion

Gene: Il33  |  Organism: Mus musculus
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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