Recombinant Mouse Kit ligand (Kitlg), partial (Active), Mus musculus (Mouse), Mammalian cell, C-terminal hFc1-tagged, 47.2 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Mouse Kit ligand (Kitlg), partial (Active)

Recombinant Mouse Kit ligand (Kitlg), partial (Active) — Ligand for the receptor-type protein-tyrosine kinase KIT. Purity >95%.

SKU: BCACP-000569 Category:
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Product SKUBCACP-000569
Product DescriptionRecombinant Mouse Kit ligand (Kitlg) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 26-189aa. [Accession | P20826].
Uniprot No.P20826
Gene NamesKitlg
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region26-189aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal hFc1-tagged
Molecular weight47.2 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis TNFRSF1A at 2 μg/mL can bind Human TNF. The EC50 is 10.33-12.16 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesKit ligand; Hematopoietic growth factor KL; Mast cell growth factor; MGF; Steel factor; Stem cell factor; SCF; c-Kit ligand [Cleaved into: Soluble KIT ligand; sKITLG]

Function

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways.

Product Specifications

Recombinant Mouse Kit ligand (Kitlg), partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 26-189aa, with C-terminal hFc1-tagged tag, molecular weight 47.2 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis TNFRSF1A at 2 μg/mL can bind Human TNF. The EC50 is 10.33-12.16 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins

Gene: Kitlg  |  Organism: Mus musculus

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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