Recombinant Mouse Pyridoxal phosphate phosphatase (Pdxp), Mus musculus (Mouse), E.coli, N-terminal 6xHis-SUMO-tagged, 47.5kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Mouse Pyridoxal phosphate phosphatase (Pdxp)

Recombinant Mouse Pyridoxal phosphate phosphatase (Pdxp) — Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5′-phosphate (PNP) and pyridoxamine 5′-phosphate (PMP), with order of substrate prefer… Purity >90%.

SKU: BCRECP-004045 Categories: ,
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Product Specifications

Product SkuBCRECP-004045
Product DescriptionRecombinant Mouse Pyridoxal phosphate phosphatase (Pdxp) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-292aa. [Accession | P60487].
Uniprot No.P60487
Gene NamesPdxp
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-292aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight47.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis.

Biological Context

Subcellular Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton; Cell projection, ruffle membrane (Peripheral membrane protein); Cell projection, lamellipodium membrane (Peripheral membrane protein); Cell membrane (Peripheral membrane protein)
Tissue Specificity: Ubiquitous. highly expressed in brain (at protein level)

Product Specifications

Recombinant Mouse Pyridoxal phosphate phosphatase (Pdxp) is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1-292aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 47.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism (PubMed:24338473, PubMed:24338687, PubMed:25783190). Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine (By similarity)

Subcellular Location

Cytoplasm, cytosol; Cytoplasm, cytoskeleton; Cell projection, ruffle membrane (Peripheral membrane protein); Cell projection, lamellipodium membrane (Peripheral membrane protein); Cell membrane (Peripheral membrane protein)

Tissue Specificity

Ubiquitous. highly expressed in brain (at protein level)

Subunit

Homodimer

Gene: Pdxp  |  Organism: Mus musculus  |  Synonyms: Pyridoxal 5'-phosphate phosphatase; Pyridoxal phosphate phosphatase
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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