Recombinant Mouse Retinal dehydrogenase 2 (Aldh1a2), Mus musculus (Mouse), E.coli, N-terminal 6xHis-tagged, 62.6kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Mouse Retinal dehydrogenase 2 (Aldh1a2)

Recombinant Mouse Retinal dehydrogenase 2 (Aldh1a2) — Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-tran… Purity >85%.

SKU: BCRECP-002060 Categories: ,
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Product Specifications

Product SkuBCRECP-002060
Product DescriptionRecombinant Mouse Retinal dehydrogenase 2 (Aldh1a2) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 1-518aa. [Accession | Q62148].
Uniprot No.Q62148
Gene NamesAldh1a2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-518aa
SpeciesMus musculus (Mouse)
Tag InfoN-terminal 6xHis-tagged
Molecular weight62.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively. Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein.

Biological Context

Subcellular Location: Cytoplasm
Pathway: Cofactor metabolism; retinol metabolism

Product Specifications

Recombinant Mouse Retinal dehydrogenase 2 (Aldh1a2) is a recombinant protein from Mus musculus (Mouse), expressed in E.coli, covering amino acids 1-518aa, with N-terminal 6xHis-tagged tag, molecular weight 62.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (PubMed:15911617, PubMed:8797830). Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Lacks activity with benzaldehyde, acetaldehyde and octanal (PubMed:8797830). Displays complete lack of activity with citral (By similarity)

Subcellular Location

Cytoplasm

Subunit

Homotetramer

Pathway

Cofactor metabolism; retinol metabolism

Gene: Aldh1a2  |  Organism: Mus musculus  |  Synonyms: Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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