Recombinant Mouse Urokinase-type plasminogen activator (Plau) (Active), Mus musculus (Mouse), Mammalian cell, C-terminal 10xHis-tagged, 47.4 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Mouse Urokinase-type plasminogen activator (Plau) (Active)

Recombinant Mouse Urokinase-type plasminogen activator (Plau) (Active) — Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin. Purity >95%.

SKU: BCACP-000507 Categories: ,
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Product SKUBCACP-000507
Product DescriptionRecombinant Mouse Urokinase-type plasminogen activator (Plau) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 21-433aa. [Accession | P06869].
Uniprot No.P06869
Gene NamesPlau
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region21-433aa
SpeciesMus musculus (Mouse)
Tag InfoC-terminal 10xHis-tagged
Molecular weight47.4 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human CCR1 at 10 μg/mL can bind Anti-CCR1 recombinant antibody. The EC50 is 9.690-10.94 ng/mL.The VLPs is negative control.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesUrokinase-type plasminogen activator; U-plasminogen activator; uPA; EC 3.4.21.73 [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]

Function

Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin. Secreted as an inactive zymogen, it is recruited and activated at the cell surface through interaction with the urokinase plasminogen activator receptor (uPAR). Cell-surface activation enables localized, plasmin-dependent pericellular proteolysis, regulating extracellular matrix degradation in cell migration and tissue remodeling.

Product Specifications

Recombinant Mouse Urokinase-type plasminogen activator (Plau) (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 21-433aa, with C-terminal 10xHis-tagged tag, molecular weight 47.4 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR1 at 10 μg/mL can bind Anti-CCR1 recombinant antibody. The EC50 is 9.690-10.94 ng/mL.The VLPs is negative control.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin (PubMed:28611361, PubMed:30707839). Secreted as an inactive zymogen, it is recruited and activated at the cell surface through interaction with the urokinase plasminogen activator receptor (uPAR). Cell-surface activation enables localized, plasmin-dependent pericellular proteolysis, regulating extracellular matrix degradation in cell migration and tissue remodeling (By similarity). Also contributes to fibrinolysis and blood clot clearance by promoting plasmin generation (PubMed:8650190)

Gene: Plau  |  Organism: Mus musculus

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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