Recombinant Neisseria meningitidis serogroup B Factor H binding protein (fhbP), Neisseria meningitidis serogroup B (strain MC58), E.coli, N-terminal 6xHis-SUMO-tagged, 39.9kDa, purity >95% as determined by SDS-PAGE.

Recombinant Neisseria meningitidis serogroup B Factor H binding protein (fhbP)

Recombinant Neisseria meningitidis serogroup B Factor H binding protein (fhbP) — A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N. Purity >95%.

SKU: BCRECP-002735 Category:
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Product Specifications

Product SkuBCRECP-002735
Product DescriptionRecombinant Neisseria meningitidis serogroup B Factor H binding protein (fhbP) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 20-274aa. [Accession | Q9JXV4].
Uniprot No.Q9JXV4
Gene NamesfhbP
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region20-274aa
SpeciesNeisseria meningitidis serogroup B (strain MC58)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight39.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties. fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable).

Biological Context

Subcellular Location: Cell outer membrane (Lipid-anchor); Secreted; Extracellular vesicle, bacterial extracellular vesicle

Product Specifications

Recombinant Neisseria meningitidis serogroup B Factor H binding protein (fhbP) is a recombinant protein from Neisseria meningitidis serogroup B (strain MC58), expressed in E.coli, covering amino acids 20-274aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 39.9kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties (PubMed:16751403). fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice (PubMed:12642606, PubMed:15039331, PubMed:15664958, PubMed:21753121, PubMed:23133374)

Subcellular Location

Cell outer membrane (Lipid-anchor); Secreted; Extracellular vesicle, bacterial extracellular vesicle

Subunit

Binds to host factor H (fH from human) (PubMed:16751403, PubMed:16785547, PubMed:19225461, PubMed:23133374). Both fHbp beta-barrels contact Sushi domains 6 and 7 in fH (also called complement control protein domains, CCP). This interaction probably mimics the normal (carbohydrate-dependent) mode of fH recruitment, regulating fH activity. Sucrose octasulphate inhibits the fHbp-fH interaction (PubMed:16785547, PubMed:19225461, PubMed:23133374)

Gene: fhbP  |  Organism: Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)  |  Synonyms: Genome-derived Neisseria antigen 1870; Lipoprotein 2086
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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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