Recombinant Neisseria meningitidis serogroup B Neisserial heparin binding antigen (nhba), Neisseria meningitidis serogroup B (strain MC58), E.coli, C-terminal 6xHis-tagged, 55.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Neisseria meningitidis serogroup B Neisserial heparin binding antigen (nhba)

Recombinant Neisseria meningitidis serogroup B Neisserial heparin binding antigen (nhba) — [C2 fragment] Localizes to host mitochondria when applied to the apical side of human endothelial cell layers, where it induces production of reactive oxygen species which lead to increased permeab… Purit…

SKU: BCRECP-003872 Category:
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Product Specifications

Product SkuBCRECP-003872
Product DescriptionRecombinant Neisseria meningitidis serogroup B Neisserial heparin binding antigen (nhba) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 18-488aa. [Accession | Q7DD37].
Uniprot No.Q7DD37
Gene Namesnhba
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region18-488aa
SpeciesNeisseria meningitidis serogroup B (strain MC58)
Tag InfoC-terminal 6xHis-tagged
Molecular weight55.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

[C2 fragment] Localizes to host mitochondria when applied to the apical side of human endothelial cell layers, where it induces production of reactive oxygen species which lead to increased permeability of host endothelial cells. The C1 fragment (which lacks the first 14 residues of C2) does not have this effect. It is not known if this occurs during Neisseria infections.

Biological Context

Subcellular Location: Host mitochondrion

Product Specifications

Recombinant Neisseria meningitidis serogroup B Neisserial heparin binding antigen (nhba) is a recombinant protein from Neisseria meningitidis serogroup B (strain MC58), expressed in E.coli, covering amino acids 18-488aa, with C-terminal 6xHis-tagged tag, molecular weight 55.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

[C2 fragment] Localizes to host mitochondria when applied to the apical side of human endothelial cell layers, where it induces production of reactive oxygen species which lead to increased permeability of host endothelial cells. The C1 fragment (which lacks the first 14 residues of C2) does not have this effect. It is not known if this occurs during Neisseria infections

Subcellular Location

Host mitochondrion

Subunit

The C-terminal beta-barrel forms a monomer

Gene: nhba  |  Organism: Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)  |  Synonyms: Genome-derived Neisseria antigen 2132
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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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