Recombinant Rat Synaptotagmin-12 (Syt12) Protein, Rattus norvegicus (Rat), in vitro E.coli expression system, N-terminal 6xHis-tagged, 50.7kDa, purity >85% as determined by SDS-PAGE.

Recombinant Rat Synaptotagmin-12 (Syt12) Protein

Recombinant Rat Synaptotagmin-12 (Syt12) Protein — Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Purity >85%.

SKU: BCRECP-00253TM Category:
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Product Specifications

Uniprot No.P97610
Gene NamesSyt12
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-421aa
SpeciesRattus norvegicus (Rat)
Tag InfoN-terminal 6xHis-tagged
Molecular weight50.7kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus.

Biological Context

Subcellular Location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (Single-pass membrane protein)
Tissue Specificity: Expressed in the brain, specifically in neurons of the cerebellum, cortex, hippocampus, olfactory bulb, brainstem and spinal cord (at protein level)

Product Specifications

Recombinant Rat Synaptotagmin-12 (Syt12) Protein is a recombinant protein from Rattus norvegicus (Rat), expressed in in vitro E.coli expression system, covering amino acids 1-421aa, with N-terminal 6xHis-tagged tag, molecular weight 50.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (PubMed:17190793). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (PubMed:17190793). Essential for mossy-fiber long-term potentiation in the hippocampus (By similarity)

Subcellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane (Single-pass membrane protein)

Tissue Specificity

Expressed in the brain, specifically in neurons of the cerebellum, cortex, hippocampus, olfactory bulb, brainstem and spinal cord (at protein level)

Subunit

Homodimer (By similarity). Can also form heterodimers (By similarity). Interacts with SYT1 (PubMed:17190793)

Gene: Syt12  |  Organism: Rattus norvegicus  |  Synonyms: Synaptotagmin XII; Synaptotagmin-related gene 1 protein

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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