Recombinant Sheep Interferon tau-1 (IFNT1), Ovis aries (Sheep), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 25kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Sheep Interferon tau-1 (IFNT1)

Recombinant Sheep Interferon tau-1 (IFNT1) — Paracrine hormone primarily responsible for maternal recognition of pregnancy. Purity >95%.

SKU: BCRECP-003081 Categories: ,
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Product Specifications

Product SkuBCRECP-003081
Product DescriptionRecombinant Sheep Interferon tau-1 (IFNT1) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 24-195aa. [Accession | P56828].
Uniprot No.P56828
Gene NamesIFNT1
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region24-195aa
SpeciesOvis aries (Sheep)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight25kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm

Product Specifications

Recombinant Sheep Interferon tau-1 (IFNT1) is a recombinant protein from Ovis aries (Sheep), expressed in E.coli, covering amino acids 24-195aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 25kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible

Subcellular Location

Secreted

Tissue Specificity

Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm

Gene: IFNT1  |  Organism: Ovis aries  |  Synonyms: Antiluteolysin; Trophoblast antiluteolytic protein; Trophoblast protein 1; Trophoblastin
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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