Recombinant Streptococcus pyogenes serotype M6 Streptolysin O (slo) Protein, Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394), in vitro E.coli expression system, N-terminal 10xHis-tagged, 65.2kDa, purity >90% as determined by SDS-PAGE.

Recombinant Streptococcus pyogenes serotype M6 Streptolysin O (slo) Protein

Recombinant Streptococcus pyogenes serotype M6 Streptolysin O (slo) Protein — A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. Purity >90%.

SKU: BCRECP-00479TM Category:
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Product Specifications

Uniprot No.Q5XE40
Gene Namesslo
PurityGreater than 90% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-571aa
SpeciesStreptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)
Tag InfoN-terminal 10xHis-tagged
Molecular weight65.2kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus.

Product Specifications

Recombinant Streptococcus pyogenes serotype M6 Streptolysin O (slo) Protein is a recombinant protein, expressed in in vitro E.coli expression system, covering amino acids 1-571aa, with N-terminal 10xHis-tagged tag, molecular weight 65.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not Test

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation

Gene: slo  |  Organism: Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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