Recombinant Thioredoxin-interacting protein (TXNIP) Protein, Homo sapiens(Human), in vitro E.coli expression system, N-terminal 6xHis-SUMO-tagged, 59.7kDa, purity >90% as determined by SDS-PAGE.

Recombinant Thioredoxin-interacting protein (TXNIP) Protein

Recombinant Thioredoxin-interacting protein (TXNIP) Protein — May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Purity >90%.

SKU: BCRECP-00662TM Category:
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Product Specifications

Uniprot No.Q9H3M7
Gene NamesTXNIP
PurityGreater than 90% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-391aa
SpeciesHomo sapiens(Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight59.7kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest.

Biological Context

Subcellular Location: Cytoplasm; Nucleus

Product Specifications

Recombinant Thioredoxin-interacting protein (TXNIP) Protein is a recombinant protein from Homo sapiens(Human), expressed in in vitro E.coli expression system, covering amino acids 1-391aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 59.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850)

Subcellular Location

Cytoplasm; Nucleus

Subunit

Homodimer; disulfide-linked (PubMed:23519408). Interacts with TXN/thioredoxin through its redox-active site (PubMed:17603038). Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (PubMed:12821938). Interacts with DDIT4 (PubMed:21460850)

Gene: TXNIP  |  Organism: Homo sapiens  |  Synonyms: Thioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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