Recombinant Tick-borne encephalitis virus Far Eastern subtype Genome polyprotein, partial — Replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. Purity >85%.
| Product Sku | BCRECP-003511 |
| Product Description | Recombinant Tick-borne encephalitis virus Far Eastern subtype Genome polyprotein, partial Protein is expressed from Baculovirus with C-terminal 6xHis-tagged. It contains 281-727aa. [Accession | P07720]. |
| Uniprot No. | P07720 |
| Purity | Greater than 85% as determined by SDS-PAGE. |
| Expression System | Baculovirus |
| Expression Region | 281-727aa |
| Species | Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus) |
| Tag Info | C-terminal 6xHis-tagged |
| Molecular weight | 51.5kDa |
| Activity | Please contact us to obtain bioactivity data. |
| Buffer | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose. |
| Storage | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
| Research Areas | Others |
Replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions.
Recombinant Tick-borne encephalitis virus Far Eastern subtype Genome polyprotein, partial — Replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. Purity >85%. Suitable for ELISA and Western Blot applications. Explore more Viral Antigen proteins →
Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.
Biological Activity: Please contact us to obtain bioactivity data.
Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.
Replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in RNA genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway
Host endoplasmic reticulum membrane (Peripheral membrane protein); Host nucleus
Homodimer (By similarity). Interacts with host STAT2; this interaction inhibits the phosphorylation of the latter, and, when all viral proteins are present (polyprotein), targets STAT2 for degradation (By similarity). Interacts with serine protease NS3 (By similarity). Interacts (via C-terminus) with host SCRIB (via PDZ3); this interaction targets NS5 to the cell membrane periphery and nucleus, thereby allowing efficient host nuclear STAT1 inhibition (By similarity)
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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.
Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.
Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.
Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.
