Recombinant Vaccinia virus Protein K3 (VACWR034), Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)), E.coli, N-terminal 6xHis-SUMO-tagged, 26.6kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Vaccinia virus Protein K3 (VACWR034)

Recombinant Vaccinia virus Protein K3 (VACWR034) — Viral mimic of EIF2S1/eIF-2alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Purity >90%.

SKU: BCRECP-004705 Categories: ,
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Product Specifications

Product SkuBCRECP-004705
Product DescriptionRecombinant Vaccinia virus Protein K3 (VACWR034) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-88aa. [Accession | P18378].
Uniprot No.P18378
Gene NamesVACWR034
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-88aa
SpeciesVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight26.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Viral mimic of EIF2S1/eIF-2alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase. Inhibits therefore EIF2S1/eIF-2alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff. Determinant of host species specificity.

Product Specifications

Recombinant Vaccinia virus Protein K3 (VACWR034) is a recombinant protein, expressed in E.coli, covering amino acids 1-88aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 26.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Viral mimic of EIF2S1/eIF-2alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase (PubMed:8099586, PubMed:9199350). Inhibits therefore EIF2S1/eIF-2alpha phosphorylation by host EIF2AK2/PKR kinase and prevents protein synthesis shutoff (PubMed:8099586, PubMed:9199350). Determinant of host species specificity (PubMed:32056708)

Organism: Vaccinia virus (strain Western Reserve)

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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