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Recombinant Varicella-zoster virus Envelope glycoprotein E (gE) Protein

Recombinant Varicella-zoster virus Envelope glycoprotein E (gE) Protein — The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Purity >85%.

SKU: BCRECP-00615TM Categories: ,

Product Specifications

Uniprot No.P09259
Gene NamesgE
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region31-623aa
SpeciesVaricella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Tag InfoN-terminal 10xHis-SUMO-tagged
Molecular weight85.4kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-VZV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses.

Biological Context

Subcellular Location: Virion membrane (Single-pass type I membrane protein); Host cell membrane (Single-pass type I membrane protein); Host cell junction; Host Golgi apparatus membrane (Single-pass membrane protein); Host endosome membrane (Single-pass membrane protein)

Product Specifications

Recombinant Varicella-zoster virus Envelope glycoprotein E (gE) Protein is a recombinant protein from Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3), expressed in in vitro E.coli expression system, covering amino acids 31-623aa, with N-terminal 10xHis-SUMO-tagged tag, molecular weight 85.4kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Protein Biology

Function

The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-VZV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses (By similarity)

Subcellular Location

Virion membrane (Single-pass type I membrane protein); Host cell membrane (Single-pass type I membrane protein); Host cell junction; Host Golgi apparatus membrane (Single-pass membrane protein); Host endosome membrane (Single-pass membrane protein)

Subunit

Interacts (via N-terminus) with host receptor IDE (via N-terminus). Interacts with gI; this interaction enhances the Fc receptor function of gE (By similarity). The heterodimer gE/gI interacts with the Fc part of host IgG

Gene: gE  |  Organism: Varicella-zoster virus (strain Dumas)

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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