Recombinant Human herpesvirus 2 Envelope glycoprotein E (gE) Protein, Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2), in vitro E.coli expression system, N-terminal 10xHis-tagged, 60.1kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human herpesvirus 2 Envelope glycoprotein E (gE) Protein

Recombinant Human herpesvirus 2 Envelope glycoprotein E (gE) Protein — The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Purity >90%.

SKU: BCRECP-00136TM Categories: ,
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Product Specifications

Uniprot No.P89475
Gene NamesgE
PurityGreater than 90% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region21-545aa
SpeciesHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Tag InfoN-terminal 10xHis-tagged
Molecular weight60.1kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-HSV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses.

Biological Context

Subcellular Location: Virion membrane (Single-pass type I membrane protein); Host cell membrane (Single-pass type I membrane protein); Host cell junction; Host Golgi apparatus membrane (Single-pass membrane protein); Host endosome membrane (Single-pass membrane protein)

Product Specifications

Recombinant Human herpesvirus 2 Envelope glycoprotein E (gE) Protein is a recombinant protein from Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2), expressed in in vitro E.coli expression system, covering amino acids 21-545aa, with N-terminal 10xHis-tagged tag, molecular weight 60.1kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

The heterodimer gE/gI serves as a receptor for the Fc part of host IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-HSV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host IgG-mediated immune responses (By similarity)

Subcellular Location

Virion membrane (Single-pass type I membrane protein); Host cell membrane (Single-pass type I membrane protein); Host cell junction; Host Golgi apparatus membrane (Single-pass membrane protein); Host endosome membrane (Single-pass membrane protein)

Subunit

Interacts with gI; this interaction enhances the Fc receptor function of gE. The heterodimer gE/gI interacts with the Fc part of host IgG. Interacts (via C-terminus) with VP22 tegument protein; this interaction is necessary for the recruitment of VP22 to the Golgi and its packaging into virions. Interacts (via C-terminus) with UL11 tegument protein (By similarity)

Gene: gE  |  Organism: Human herpesvirus 2 (strain HG52)  |  Synonyms: gE-2

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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